Enhancement in corneal permeability of riboflavin using calcium sequestering compounds
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چکیده
منابع مشابه
Enhancement in corneal permeability of riboflavin using calcium sequestering compounds
Ethylenediaminetetraacetic acid, ethylenediamine-N,N'-disuccinic acid and ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid are polyaminocarboxylic acids that are able to sequester metal ions. Calcium is implicated in maintenance of intercellular matrix, zonula occludens (tight junctions) and zonula adherens of epithelium and endothelium cells. Corneal epithelium is impervious t...
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PURPOSE To investigate the effect of cross-linking treatment on corneal permeability in a live animal model. METHODS Rabbit eyes were selected at random to be left unoperated or to undergo epithelial debridement with or without treatment consisting of cross-linking (CXL) with riboflavin and ultraviolet-A. Nine eyes received a total dose of 3.6 J/cm² and after epithelial healing the corneas we...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2014
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2014.06.007